Diagnostic detection devices and methods
US-9207248-B2 · Dec 8, 2015 · US
Compositions and methods for detecting autoantibodies
US8986937B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8986937-B2 |
| Application number | US-201113228705-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 9, 2011 |
| Priority date | Sep 9, 2011 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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Abstract
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The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions.
First claim
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We claim: 1. A method for detecting thyroid hormone blocking immunoglobulin (TBI) in a sample, comprising a) combining i) transgenic cells stably transfected with one or more expression vector comprising a 1) a first nucleic acid sequence that encodes a reporter, wherein said first nucleotide sequence is operably linked to a cAMP-inducible promoter, and 2) the nucleotide sequence of SEQ ID NO: 2 that encodes a chimeric TSH receptor (TSHR), wherein said SEQ ID NO: 2 is operably…
Assignees
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- G01N33/76Primary
Physics · mapped topic
Physics · mapped topic
- G01N33/566Primary
Physics · mapped topic
- G01N33/564Primary
Physics · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US8986937B2 cover?
- The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress o…
- Who is the assignee on this patent?
- Li Yunsheng, Olivo Paul D, Kim Jaekyung, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/76. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).