Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity
US-2024426772-A1 · Dec 26, 2024 · US
US8986928B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8986928-B2 |
| Application number | US-75778910-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 9, 2010 |
| Priority date | Apr 10, 2009 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
Opening claim text (preview).
We claim: 1. A device for determining polymer sequence information comprising: a substrate comprising an array of nanopores; each nanopore fluidically connected to a separate upper fluidic region and to a lower fluidic region; wherein each upper fluidic region is fluidically connected through an upper resistive opening to an upper liquid volume, wherein each nanopore's lower fluidic region is separate and is fluidically connected through a lower resistive opening to a lower liquid…
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