Macrocyclic compounds and methods of use
US-2024294551-A1 · Sep 5, 2024 · US
US8980906B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980906-B2 |
| Application number | US-201314105733-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2013 |
| Priority date | Dec 14, 2012 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
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The application is directed to compounds of Formula I-A and pharmaceutically acceptable salts and solvates thereof, wherein , R 1a —R 3a , R 4 , Y and Z a are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
Opening claim text (preview).
What is claimed is: 1. A compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 is hydrogen, OH, halo, cyano, carboxy, or aminocarbonyl; or alkyl, alkenyl, alkynyl, alkoxy alkenyloxy or alkynyloxy, any of which is optionally substituted with 1, 2, or 3 substituents, each independently selected from the group consisting of hydroxy, halo,…
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