Pyrazole derivative

Patent metadata

Field	Value
Publication number	US-8980888-B2
Application number	US-201414477672-A
Country	US
Kind code	B2
Filing date	Sep 4, 2014
Priority date	Feb 27, 2013
Publication date	Mar 17, 2015
Grant date	Mar 17, 2015

Abstract

It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g. mental disorder and neurodegenerative disorder). The present invention provides: compounds having PDE10 inhibitory effect, in particular, compounds having a 4-heteroarylpyrazole-5-carboxylic acid amide structure represented by the following formula (I), or their pharmaceutically acceptable salts, or their solvates; pharmaceutical compositions comprising, as active ingredients, the compounds, or their pharmaceutically acceptable salts, or their solvates; and medical use of the compounds, or their pharmaceutically acceptable salts, or their solvates.

First claim

The invention claimed is:

1. A compound represented by the following formula (I-d):

or a pharmaceutically acceptable salt thereof, or a solvate thereof,
wherein
p represents an integer of 0 to 4;
q represents an integer of 0 to 3;
Z represents N or CR 5 ;
R 1 each independently represents a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C…

Assignees

• Mochida Pharm Co Ltd

Inventors

• Okano Akihiro
• Makabe Muneyoshi
• Ogawa Kouki

Classifications

• A61P43/00

  Human Necessities · mapped topic

• A61P25/14

  Human Necessities · mapped topic

• A61P25/16

  Human Necessities · mapped topic

• A61P25/30

  Human Necessities · mapped topic

• A61P25/22

  Human Necessities · mapped topic