Use of polypeptides with calcium indicator activity for identifying the activity of insecticidal proteins
US-2024426834-A1 · Dec 26, 2024 · US
US8980859B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980859-B2 |
| Application number | US-201313746631-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2013 |
| Priority date | Jul 9, 2007 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
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The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
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The invention claimed is: 1. A method of disrupting platelet adhesion in a subject comprising: identifying a subject in need of a molecule that disrupts platelet adhesion and providing said subject with a therapeutically effective amount of said molecule, wherein said molecule is a nucleic acid encoding an Aegyptin polypeptide or fragment thereof. 2. The method of claim 1 , wherein said subject is human. 3. A method of reducing clot formatio…
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