Pyrimidine pyrazolyl derivatives
US-9216991-B2 · Dec 22, 2015 · US
US8980587B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980587-B2 |
| Application number | US-201113819959-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 30, 2011 |
| Priority date | Aug 31, 2010 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
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A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.
Opening claim text (preview).
The invention claimed is: 1. A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, wherein the synthetic intermediate is selected from the group consisting of wherein the bacterium has been modified so as to…
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