St2 antigen binding proteins
US-2024368292-A1 · Nov 7, 2024 · US
Site-specific antibody-mediated activation of proapoptotic cytokines: AMAIZEe (antibody-mediated apoptosis inducing cytokines)
US8980265B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980265-B2 |
| Application number | US-38922303-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2003 |
| Priority date | Sep 15, 2000 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein to a specific cell membrane-expressed target molecule. By suitable choice of the antibody specificity, the cytokine activity is directed to the tissue, e.g. tumor tissue, to be treated, and a therapeutic agent can be produced being specifically designed/optimized for the respective indication/tumor entity.
First claim
Opening claim text (preview).
What is claimed is: 1. A polypeptide comprising: (i) a segment (1) that is FasL extracellular domain consisting of the amino acid sequence of SEQ ID NO: 14; (ii) a segment (2) comprising a non-multimerizing peptide linker that is linked to the N-terminus of segment (1), wherein the amino acid sequence of the linker consists of the sequence selected from the group consisting of AAAVELE (SEQ ID NO: 21), RTVAAPSVFAVFAAAVELE (SEQ ID NO: 20) and RTVAAPSVFAVFAAA (SEQ ID NO: 22); and…
Assignees
Inventors
Classifications
Patent family
Related publications grouped by family.
External sources
Next steps
Free tools are coming soon. Tell us what you want to track and we'll notify you.
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US8980265B2 cover?
- Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein…
- Who is the assignee on this patent?
- Pfizenmaier Klaus, Wajant Harald, Moosmayer Dieter, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2866. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 17 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).