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Bispecific single chain Fv antibody molecules and methods of use therof
US8980258B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980258-B2 |
| Application number | US-201213710146-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 10, 2012 |
| Priority date | Apr 5, 2002 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
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Abstract
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Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
First claim
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What is claimed is: 1. A method for treating a cancer that overexpresses HER2 and/or HER3 proteins, said method comprising administering to a patient in need thereof a therapeutically effective amount of a bispecific antibody molecule comprising a first scFv antibody that binds HER2/neu and a second scFv antibody that binds HER3, wherein the first scFv antibody binds an epitope of HER2/neu specifically bound by antibody C6-B1D2 and the second scFv antibody binds an epitope of HER3…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8980258B2 cover?
- Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
- Who is the assignee on this patent?
- Univ California, Fox Chase Cancer Ct
- What technology area does this patent fall under?
- Primary CPC classification A61K39/395. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 17 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).