Method for Cancer Therapy Based on Co-Administration of a Parvovirus and a Cytokine
US-2016367609-A1 · Dec 22, 2016 · US
Parvovirus methods and compositions for killing neoplastic cells
US8980247B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8980247-B2 |
| Application number | US-201113324484-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2011 |
| Priority date | Oct 21, 2004 |
| Publication date | Mar 17, 2015 |
| Grant date | Mar 17, 2015 |
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Abstract
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According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursors, while leaving healthy cells intact. The invention also includes a method of killing cancer and other neoplastic and preneoplastic cells by administrating to said cells the AAV2 proteins Rep78 or Rep 68, expression constucts encoding the same, or pharmaceutical compositions comprising the same.
First claim
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What is claimed is: 1. A method of treating or ameliorating cancer comprising administering to a patient having cancer, a recombinant protein comprising AAV2 Rep68 and AAV2 Rep78, and inducing an increase in S-phase entry in cancer cells in said patient, wherein said treatment or amelioration of said cancer is performed without inclusion of any additional anti-cancer compound, chemotherapeutic agent, or other DNA damaging agent. 2. The method of claim 1 w…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8980247B2 cover?
- According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursors, while leaving healthy cells intact. The invention also includes a method of killing cancer and other neoplastic and preneoplastic cells by administrating to said cells the AAV2 proteins Rep78 or Rep 68, express…
- Who is the assignee on this patent?
- Meyers Craig M, Alam Samina, Penn State Res Found
- What technology area does this patent fall under?
- Primary CPC classification A61K35/768. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 17 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).