2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders
US-9221816-B2 · Dec 29, 2015 · US
US8975418B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975418-B2 |
| Application number | US-201314013097-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 29, 2013 |
| Priority date | Sep 4, 2012 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.
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What is claimed is: 1. A method of preparing a compound of formula (B) wherein R and R′ may be the same or different, and are each independently selected from C 1-4 -alkyl (e.g. methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, or tert-butyl), or R and R′ together are a —CH 2 —, —CH 2 CH 2 — or —C(CH 3 ) 2 — group, said method comprising reacting…
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