Labeling reagents for analyte determination and methods and compounds used in making the same

Patent metadata

Field	Value
Publication number	US-8975404-B2
Application number	US-62568807-A
Country	US
Kind code	B2
Filing date	Jan 22, 2007
Priority date	Jan 24, 2006
Publication date	Mar 10, 2015
Grant date	Mar 10, 2015

Abstract

Provided herein are labeling reagents for analyte determination in a sample, and methods of manufacturing the labeling reagents. By way of non-limiting example, analytes may include one or more of peptides, proteins, nucleic acid molecules, carbohydrates, lipids, steroids and/or small molecules. Also provided are labeled analytes themselves after one or more labeling reagents binds to an analyte. Analytes may be labeled for determination of the analyte by mass analysis, such as by mass spectrometry. Further provided are compounds that may be used in making the labeling reagents and labeled analytes, such as reporter group compounds. Also provided are kits that include at least one labeling reagent, and may further include or more other reagents, containers, enzymes, buffers, a labeled analyte (e.g., as a standard) and/or instructions. Further examples are also possible.

First claim

We claim:

1. A compound represented by formula I;

or a salt form thereof; wherein
Y is a piperazine moiety that may be substituted or unsubstituted and that may optionally be cleavably linked to a support, wherein the piperazine moiety comprises at least one ring nitrogen atom that is linked through a covalent bond to the group J;
J is a group represented by…

Assignees

• Pillai Sasi K
• Dey Subhakar
• Purkayastha Subhasish
• Pappin Darryl J C
• Dh Technologies Dev Pte Ltd

Inventors

• Pillai Sasi K
• Dey Subhakar
• Purkayastha Subhasish
• Pappin Darryl J C

Classifications

• C07D403/12

  Chemistry & Metallurgy · mapped topic

• C07D295/15 Primary

  Chemistry & Metallurgy · mapped topic

• G01N33/58

  Physics · mapped topic

• G01N33/6848

  Physics · mapped topic