Methods for treatment of cancer with an anti-tigit antagonist antibody
US-2024424092-A1 · Dec 26, 2024 · US
US8975375B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975375-B2 |
| Application number | US-201113086176-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 13, 2011 |
| Priority date | Sep 12, 2005 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
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The invention claimed is: 1. A pharmaceutical composition, comprising a monoclonal antibody which (I) inhibits activity of a tumor-associated antigen; and/or (II) has tumor-inhibiting activity, and is selective for cells expressing or abnormally expressing a tumor-associated antigen, the tumor-associated antigen having a sequence encoded by a nucleic acid that is: (a) a nucleic acid which comprises the nucleic acid sequence of SEQ ID NO. 1, or (b) a nucleic acid that has at l…
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