F2 derivatives as antibacterial agents

Patent metadata

Field	Value
Publication number	US-8975288-B2
Application number	US-201313833976-A
Country	US
Kind code	B2
Filing date	Mar 15, 2013
Priority date	Apr 10, 2012
Publication date	Mar 10, 2015
Grant date	Mar 10, 2015

Abstract

A compound or its pharmaceutically acceptable salt, as well as a pharmaceutical, composition containing that compound or salt dissolved or dispersed in a pharmaceutically acceptable carrier, and a method of using that compound or salt in an antibacterial treatment. A contemplated compound corresponds in structure to structural Formula I or a pharmaceutically acceptable salt of that compound, wherein V is O or NR 9 , Y is halogen, OR 10 , C 1 -C 4 hydrocarbyl or NHR 10 , Z is NR 2 —X—R 1 or CH 2 —R 8 , n is 1-6, X is H, S(O) 2 , C(O), C(O)NR 7 , C(NH)NR 7 or C(O)O, and R 1 , R 2 , R 7 , R 8 , R 9 and R 10 are defined within.

First claim

The invention claimed is:

1. A compound of structural Formula I or a pharmaceutically acceptable salt of that compound

wherein n is 1-6;
V is O or NR 9 ;
R 9 is hydrido (H) or C 1 -C 4 hydrocarbyl;
Z is NR 2 —X—R 1 or CH 2 —R 8 ;
X is hydrido (H), S(O) 2 , C(O), C(O)NR 7 , C(NH)NR 7 or C(O)O, with the proviso that when X is H, R 1 an…

Assignees

• Keiler Kenneth Charles
• Alumasa John Nandwa
• Penn State Res Found

Inventors

• Keiler Kenneth Charles
• Alumasa John Nandwa

Classifications

• A61P31/04

  Human Necessities · mapped topic

• C07D257/06 Primary

  Chemistry & Metallurgy · mapped topic

• A01N43/713

  Human Necessities · mapped topic

• A61K31/5355

  Human Necessities · mapped topic

• A61K31/41

  Human Necessities · mapped topic