Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
Substituted pyrazolone compounds and methods of use
US8975282B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975282-B2 |
| Application number | US-201313945924-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 19, 2013 |
| Priority date | Jul 28, 2012 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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- Title
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Abstract
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The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of Formula (I): or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein: Q is D, —N(R c )C(═O)NR a R b , —N(R c )C(═O)R d , —C(═O)NR a R b , —N(R c )S(═O)NR a R b , —N(R c )S(═O)R a , —N(R c )S(═O) 2 NR a R b or —N(R c )S(═O) 2 R…
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Classifications
Chemistry & Metallurgy · mapped topic
- C07D401/12Primary
Chemistry & Metallurgy · mapped topic
- A61K31/4439Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US8975282B2 cover?
- The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds an…
- Who is the assignee on this patent?
- Calitor Sciences Llc, Sunshine Lake Pharma Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07D401/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).