Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US8975264B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975264-B2 |
| Application number | US-201113819601-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 31, 2011 |
| Priority date | Aug 31, 2010 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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Disclosed is a novel compound acting as a cannabinoid receptor 1 inhibitor, the compound being a pyrazolo[1,5-a]pyrimidine derivative, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The novel compound or the like is useful for preventing or treating diseases mediated by the cannabinoid receptor-1.
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The invention claimed is: 1. A compound of Chemical Formula 1, a positional or optical isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof: wherein R 1 is selected from a group consisting of hydrogen, C 1 -C 5 alkyl, haloalkyl, C 1 -C 5 cycloalkyl and C 1 -C 5 alkoxyalkyl; each of R 2 and R 7 is hydrogen;…
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