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Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors
US8975261B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975261-B2 |
| Application number | US-201214117313-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 21, 2012 |
| Priority date | May 24, 2011 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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Abstract
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The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
First claim
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What is claimed is: 1. A compound of the formula I: wherein : A is C 5-10 heterocyclyl; B is a C 5-10 heterocyclyl selected from the group consisting of pyrimidinyl, naphthridinyl, pyrazinyl and pyridyl, wherein when B is pyrimidinyl it is presented by structural formula Ic:…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D487/04Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8975261B2 cover?
- The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and tho…
- Who is the assignee on this patent?
- Breslin Michael J, Cox Christopher D, Hartingh Timothy J, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).