Macrocyclic kinase inhibitors and uses thereof

Patent metadata

Field	Value
Publication number	US-8975232-B2
Application number	US-201113812431-A
Country	US
Kind code	B2
Filing date	Jul 29, 2011
Priority date	Jul 29, 2010
Publication date	Mar 10, 2015
Grant date	Mar 10, 2015

Abstract

The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R 1 , R 2 , R 3 , R 4 , R E , R F , R G , R H , R I , f, g, h, n, and m are as defined herein. The present invention further provides methods of synthesizing these macrocyclic compounds, and methods of their use and treatment. Certain aspects of the present invention relate to modulation of kinase activity, and in the treatment of kinase-associated diseases or disorders.

First claim

What is claimed is:

1. A compound of Formula (XV):

or a pharmaceutically acceptable salt thereof;
wherein:
n is 2 or 3;
m is 0;
represents a double bond in the cis or trans configuration;
p is an integer between 1 and 6, inclusive;
q is an integer between 1 and 5, inclusive;
each instance of R AA is independently halogen, substituted or unsubstitute…

Assignees

• Liu David R
• Kleiner Ralph E
• Harvard College

Inventors

• Liu David R
• Kleiner Ralph E

Classifications

• A61P35/00

  Human Necessities · mapped topic

• A61K38/12 Primary

  Human Necessities · mapped topic

• C07K5/02 Primary

  Chemistry & Metallurgy · mapped topic

• C07K5/1016

  Chemistry & Metallurgy · mapped topic