Asgpr-binding compounds for the degradation of extracellular proteins
US-2024424108-A1 · Dec 26, 2024 · US
Bone morphogenic protein binding peptide
US8975231B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8975231-B2 |
| Application number | US-201213486498-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 1, 2012 |
| Priority date | Jan 28, 2004 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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Abstract
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A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
First claim
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We claim: 1. A method of inducing osteogenesis or calcification in vertebrate tissue comprising administering to the tissue chondrogenic or osteogenic precursor cells and a peptide having the amino acid sequence of SEQ ID NO. 13, or a fragment thereof, wherein said peptide or fragment increases the degree or rate of osteogenesis or calcification. 2. The method of claim 1 wherein the chondrogenic or osteogenic precursor cells are administered to the tissue at a…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8975231B2 cover?
- A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions …
- Who is the assignee on this patent?
- Murray Samuel S, Brochmann-Murray Elsa J, Wang Jeffrey, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07K7/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).