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Disease treatment via developing non-syngeneic graft transplantation
US8974779B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8974779-B2 |
| Application number | US-66453005-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 2, 2005 |
| Priority date | Mar 6, 2003 |
| Publication date | Mar 10, 2015 |
| Grant date | Mar 10, 2015 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respectively, for providing the pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function, respectively, to the subject.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of providing a pancreatic function to a human subject, the method comprising transplanting into the subject a porcine pancreatic vascularized organ/tissue graft, wherein said porcine pancreatic vascularized organ/tissue graft is at a gestational stage of about 42 to about 56 days of gestation, thereby generating a functional porcine pancreatic organ/tissue for providing the pancreatic function to the subject. 2. The method of claim 1 , wherein the subject has an abnormal activity of a biomolecule naturally produced by a mammalian pancreas. 3. The method of claim 2 , wherein said biomolecule is insulin. 4. The method of claim 1 , wherein the subject has an abnormal activity of a biomolecule naturally produced by a mammalian pancreatic islet. 5. The method of claim 1 , further comprising transiently administering to the subject at least one T-cell costimulation inhibitor and at least one CD40 ligand inhibitor. 6. The method of claim 1 , wherein said transplanting said graft into the subject is effected by transplanting said graft under at least one renal capsule of the subject. 7. The method of claim 1 , wherein said transplanting said graft into the subject is effected into the pancreas.
Assignees
Inventors
Classifications
Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title
- A61L27/3604Primary
characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title
Respiratory system, e.g. lungs, bronchi or lung cells · CPC title
- A61K35/39Primary
Pancreas; Islets of Langerhans (Langerhans cells of epidermis A61K35/36) · CPC title
Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking · CPC title
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- What does patent US8974779B2 cover?
- A method of providing a pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue function to a mammalian subject is provided. The method comprises transplanting into the subject a developing mammalian pancreatic, lymphoid/hematopietic or pulmonary organ/tissue graft, respectively, thereby generating a functional pancreatic, lymphoid/hematopietic or pulmonary organ and/or tissue, respe…
- Who is the assignee on this patent?
- Reisner Yair, Dekel Benjamin, Eventov-Friedman Smadar, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification A61L27/3604. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).