Apparatus for localizing single fluorescent molecules comprised in a sample using single molecule localization microscopy
US-2024393250-A1 · Nov 28, 2024 · US
Spectral and temporal laser fluorescence analysis such as for natural aquatic environments
US8970841B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8970841-B2 |
| Application number | US-201013513786-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 3, 2010 |
| Priority date | Dec 4, 2009 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attributed to chlorophyll-a (Chl-a), phycobiliprotein (PBP) pigments, or chromophoric dissolved organic matter (CDOM), among others. Improved physiological assessments of photosynthesizing organisms can use SDC analysis and temporal LSE measurements to assess variable fluorescence corrected for SDC-retrieved background fluorescence. Fluorescence assessments of Chl-a concentration based on LSE spectral measurements can be improved using photo-physiological information from temporal measurements. Quantitative assessments of PBP pigments, CDOM, and other fluorescent constituents, as well as basic structural characterizations of photosynthesizing populations, can be performed using SDC analysis of LSE spectral measurements.
First claim
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The claimed invention is:: 1. A method, comprising: stimulating a liquid, which includes dissolved and particulate matter, using a laser; obtaining a spectral measurement of a laser-stimulated emission (LSE) from the liquid; obtaining a temporal measurement of a LSE from the liquid; and determining a characteristic of a fluorescent constituent in the liquid, the determining using information from the temporal measurement of the LSE to adjust the spectral measurement of the L…
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Physics · mapped topic
- G01N21/6408Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8970841B2 cover?
- An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attri…
- Who is the assignee on this patent?
- Chekalyuk Alexander, Univ Columbia
- What technology area does this patent fall under?
- Primary CPC classification G01N21/6408. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).