Dendritic molecular intracellular transporters and methods of making and using same

Patent metadata

Field	Value
Publication number	US-8969622-B2
Application number	US-84435307-A
Country	US
Kind code	B2
Filing date	Aug 23, 2007
Priority date	Aug 23, 2006
Publication date	Mar 3, 2015
Grant date	Mar 3, 2015

Abstract

In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure:

and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

First claim

What is claimed is:

1. A compound having the structure:

2. A compound having the structure:

wherein n is 5;
wherein R 1 and R 2 are, independently, hydrogen, alkyl, a luminescent group, a biologically-active group, a pharmaceutically-active gro…

Assignees

• Harth Eva M
• Crowe Jr James E
• Huang Kui
• Hamilton Sharon K
• Hamm Heidi E
• Voss Bryan
• Univ Vanderbilt

Inventors

• Harth Eva M
• Crowe Jr James E
• Huang Kui
• Hamilton Sharon K
• Hamm Heidi E
• Voss Bryan

Classifications

• A61K49/0052

  Human Necessities · mapped topic

• Y10S977/754

  Cross-Sectional Technologies · mapped topic

• A61K47/48169 Primary

  Human Necessities · mapped topic

• C07D311/90

  Chemistry & Metallurgy · mapped topic

• A61K49/0054

  Human Necessities · mapped topic