Heterocyclic modulators of lipid synthesis
US-2024400552-A1 · Dec 5, 2024 · US
US8969563B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969563-B2 |
| Application number | US-201113825228-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 22, 2011 |
| Priority date | Sep 22, 2010 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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An object of the present invention is to provide an industrially useful method for producing a calcium salt of pyrroloquinoline quinone, without using large amounts of organic solvents, and highly pure crystals produced thereby. According to the present invention, a highly pure calcium salt of pyrroloquinoline quinone can be produced by reacting an alkali metal salt of pyrroloquinoline quinone with a source of calcium ions.
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The invention claimed is: 1. A crystal of a calcium salt of pyrroloquinoline quinone, having peaks in 2θ at 7.7°, 10.6°, 19.1°, 26.4°, and 38.6° (each within ±0.4°) in powder X-ray diffraction using Cu Kα radiation, wherein the calcium salt of pyrroloquinoline quinone has a ratio of pyrroloquinoline quinone to calcium ions of about 1:1.5. 2. A crystal of a calcium salt of pyrroloquinoline quinone, having peaks in 20 at 9.8°, 15.3°, 17.1°, 19.7°, 26.3°, and 28.3°…
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