Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor

Patent metadata

Field	Value
Publication number	US-8969552-B2
Application number	US-66542805-A
Country	US
Kind code	B2
Filing date	Oct 14, 2005
Priority date	Oct 14, 2004
Publication date	Mar 3, 2015
Grant date	Mar 3, 2015

Abstract

The present invention relates to aromatic compounds of the formula I

wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R a and wherein Ar may also carry 1 or 2 radicals R b ;
X is N or CH; Y is O, S, —CH═N—, —CH═CH— or —N═CH—; A is CH 2 , O or S; E is CR 6 R 7 or NR 3 ; R 1 is C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -cycloalkylmethyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, fluorinated C 3 -C 4 -cycloalkylmethyl, fluorinated C 3 -C 4 -alkenyl, formyl or C 1 -C 3 -alkylcarbonyl; R 1a is H, C 2 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -alkenyl, fluorinated C 1 -C 4 -alkyl, fluorinated C 3 -C 4 -cycloalkyl, or R 1a and R 2 together are (CH 2 ) n with n being 2 or 3, or R 1a and R 2a together are (CH 2 ) n with n being 2 or 3; R 2 and R 2a are independently of each other H, CH 3 , CH 2 F, CHF 2 or CF 3 ; R 3 is H or C 1 -C 4 -alkyl; R 6 , R 7 independently of each other are selected from H, C 1 -C 2 -alkyl and fluorinated C 1 -C 2 -alkyl;

and the physiologically tolerated acid addition salts thereof.

The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

First claim

We claim:

1. An aromatic compound of the formula I

wherein
Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar is substituted with 1 radical R a , wherein
R a is selected from the group consisting of C 2 -C 6 alkyl, fluorinated C 2 -C 6 alkyl, fluorinated C 3 -C 6 cycloalkyl, fluoromethyl, difluoromethyl, fluoromethoxy, difluorome…

Assignees

• Drescher Karla
• Haupt Andreas
• Unger Liliane
• Turner Sean C
• Braje Wilfried
• Grandel Roland
• Henry Christophe
• Abbvie Deutschland

Inventors

• Drescher Karla
• Haupt Andreas
• Unger Liliane
• Turner Sean C
• Braje Wilfried
• Grandel Roland
• Henry Christophe

Classifications

• A61P43/00

  Human Necessities · mapped topic

• A61P25/14

  Human Necessities · mapped topic

• A61P25/00

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic

• A61P25/28

  Human Necessities · mapped topic