Mutant fragments of ospa and methods and uses relating thereto
US-2016333056-A1 · Nov 17, 2016 · US
US8969520B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969520-B2 |
| Application number | US-201113638622-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2011 |
| Priority date | Mar 31, 2010 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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To provide a reagent for assaying anti- Treponema pallidum antibody which reagent contains a polypeptide antigen and which reagent provides high assay sensitivity and high specificity, and to provide an assay method employing the assay reagent. The reagent for assaying anti- Treponema pallidum antibody, for use in an assay of anti- Treponema pallidum antibody on the basis of antigen-antibody reaction is characterized in that the reagent contains, as an antigen, a recombinant polypeptide containing at least domain C and domain D of Treponema pallidum 47 kDa antigen but containing no domain A1 of the 47 kDa antigen.
Opening claim text (preview).
The invention claimed is: 1. A reagent for assaying anti- Treponema pallidum antibody, based on an antigen-antibody reaction, wherein the reagent comprises, as an antigen, a recombinant polypeptide comprising at least domain C and domain D of Treponema pallidum 47 kDa antigen encoded by the nucleic acid comprising SEQ ID NO:34 and lacking domain A1 of the 47 kDa antigen, wherein the domain A1 is formed of amino acids 1-34 of domain A of the Treponema pallidum 47 kDa antigen, w…
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