Substituted 2-azabicycles and their use as orexin receptor modulators

Patent metadata

Field	Value
Publication number	US-8969352-B2
Application number	US-201414206722-A
Country	US
Kind code	B2
Filing date	Mar 12, 2014
Priority date	Mar 13, 2013
Publication date	Mar 3, 2015
Grant date	Mar 3, 2015

Abstract

The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2 is H, alkyl, alkoxy, or halo; Z is NH or O; R3 is H, alkyl, alkoxy, halo, or triazolyl; R4 is H or alkyl; or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring; R5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl; and n is 1 or 2. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.

First claim

What is claimed:

1. A compound of formula I

or an enantiomer or diastereomer thereof;
or a pharmaceutically acceptable salt thereof;
wherein
X is N or CR 1 ;
Y is N or CR 2 ;
R 1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazolyl, oxadiazolyl, or pyrazolyl;
R 2 is H, alkyl, alkoxy, or halo;
Z…

Assignees

• Janssen Pharmaceutica Nv

Inventors

• Gelin Christine F
• Lebold Terry P
• Shireman Brock T

Classifications

• A61P25/00

  Human Necessities · mapped topic

• C07D413/14 Primary

  Chemistry & Metallurgy · mapped topic

• C07D401/14

  Chemistry & Metallurgy · mapped topic

• C07D417/14

  Chemistry & Metallurgy · mapped topic

• C07D403/14

  Chemistry & Metallurgy · mapped topic