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Compositions and methods for bone formation and modeling
US8969339B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969339-B2 |
| Application number | US-201213676630-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 14, 2012 |
| Priority date | Sep 22, 2003 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
First claim
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What is claimed is: 1. A method of activating a Wnt pathway, the method comprising contacting a low density lipoprotein receptor-related protein (LRP)5/6 of the Wnt pathway with a compound sufficient to inhibit the interaction of Dkk1 with a YWTD domain of the LRP5/6, wherein the compound is wherein R 15 is a linear or branched C 1-5 alkyl group. 2. T…
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Frequently asked questions
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- What does patent US8969339B2 cover?
- The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor…
- Who is the assignee on this patent?
- Enzo Biochem Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/538. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).