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Methods and compounds for preventing and treating a tumour

US8969313B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8969313-B2
Application numberUS-74091208-A
CountryUS
Kind codeB2
Filing dateNov 3, 2008
Priority dateNov 2, 2007
Publication dateMar 3, 2015
Grant dateMar 3, 2015

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherein A is CH or N, R 1 , R 4 and R 5 are independent from each other H, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group, and an arylalicyclic group comprising 0-3 heteroatoms. The heteroatoms may be N, O, S, or Si. R 4 and R 5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R 2 is H or a halogen such as F, Cl, Br or L. R 3 is H, F, Cl or an aliphatic or arylaliphatic group that includes 1-8 main chain carbon atoms and 0-3 heteroatoms. The pharmaceutical composition also comprises a histone deacetylase inhibitor.

First claim

Opening claim text (preview).

What is claimed is: 1. A method of treating colon cancer, the method comprising: increasing at least one of the amount and the activity of a DACT3 (“dapper, antagonist of beta-catenin, homolog”) protein, or a functional fragment thereof, wherein the increase in the amount and the activity of the DACT3 protein, or the functional fragment thereof is achieved by administering a combination that increases the expression and/or the activity of the DACT3 protein, or a functional fragmen…

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Frequently asked questions

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What does patent US8969313B2 cover?
The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes increasing the amount and/or the activity of a DACT protein, or a functional fragment thereof, in the cell. Also provided is a pharmaceutical composition that comprises a compound of general formula (I), wherei…
Who is the assignee on this patent?
Yu Qiang, Agency Science Tech & Res
What technology area does this patent fall under?
Primary CPC classification A61K31/437. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).