Modulators of G-Protein Coupled Receptors
US-2024383960-A1 · Nov 21, 2024 · US
Glucagon/GLP-1 receptor co-agonists
US8969294B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969294-B2 |
| Application number | US-201213567858-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 6, 2012 |
| Priority date | Jun 17, 2008 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
First claim
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The invention claimed is: 1. A pegylated glucagon peptide of the following structure: wherein “Peptide” comprises the following sequence: (SEQ ID NO: 588) X1SQGT FTSDY SKYLD ERRAK DFVC*W L…
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- What does patent US8969294B2 cover?
- Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency g…
- Who is the assignee on this patent?
- Bianchi Elisabetta, Pessi Antonello, Day Jonathan, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/605. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).