Stable injectable compositions of glp-2 peptide
US-2024415933-A1 · Dec 19, 2024 · US
Amide based glucagon and superfamily peptide prodrugs
US8969288B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969288-B2 |
| Application number | US-200913130962-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 18, 2009 |
| Priority date | Dec 19, 2008 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
First claim
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The invention claimed is: 1. A complex comprising the structure: A-B-Q; wherein Q is a glucagon superfamily peptide; A is an alpha-amino acid or an alpha-hydroxy acid, wherein when the alpha-carbon is chiral, A is in the D-stereochemical configuration; B is an N-alkylated amino acid linked to Q through an amide bond between A-B and a primary amine of Q; wherein A, B, or the amino acid of Q to which A-B is linked is a non-coded amino acid, further wherein the chemical clea…
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- What does patent US8969288B2 cover?
- Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
- Who is the assignee on this patent?
- Dimarchi Richard D, Kou Binbin, Univ Indiana Res & Tech Corp
- What technology area does this patent fall under?
- Primary CPC classification A61K38/26. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).