Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity
US-2024426772-A1 · Dec 26, 2024 · US
US8969007B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969007-B2 |
| Application number | US-201013508224-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 5, 2010 |
| Priority date | Nov 6, 2009 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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A microchamber electrochemical cell and method of using the cell for performing quantitative analysis of various charged macromolecules is presented. The microchamber electrochemical cell includes a substrate, opposing electrodes and at least one nanoslot. The substrate is configured to define a pair of opposing fluid reservoirs. The pair of opposing electrodes are respectively positioned within the opposing fluid reservoirs. Each nanoslot is configured to fluidly connect the opposing fluid reservoirs together. The opposing fluid reservoirs of the microchamber electrochemical cell are fluidly connected to each other only through each nanoslot. Each nanoslot is physically restricted to less than 500 nanometers. One method includes the steps of coupling, filling, measuring, obtaining, performing and preparing.
Opening claim text (preview).
What is claimed is: 1. A quantitative method for analyzing a macromolecule comprising: making an assay mixture containing the macromolecule; getting a microchamber electrochemical cell comprising: a substrate defining a pair of opposing fluid reservoirs; a pair of opposing electrodes in the opposing fluid reservoirs; at least one nanoslot fluidly connecting together the opposing fluid reservoirs such that the opposing fluid reservoirs are fluidly connected to each other onl…
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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