Scale-up of microfluidic devices
US-2015360186-A1 · Dec 17, 2015 · US
US8968873B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8968873-B2 |
| Application number | US-201113209183-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 12, 2011 |
| Priority date | Aug 13, 2010 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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A microfluidic device to produce polymersomes having three coaxial passageways of increasing size with fluid flowing in one direction. The first and smallest passageway contains the content of the polymersome, the middle passageway contains a block copolymer, and the largest and outer passageway contains an aqueous medium or water. The device can produce polymersomes with control of size and membrane thickness. The device will allow quantitative loading of the polymersomes in high quantities. The device is robust and easily assembled and has the ability to independently control the three streams involved in making the polymersomes.
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What is claimed is: 1. A microfluidic device for preparing encapsulation agents, comprising: a substantially rigid, continuous housing having an inlet side with an inlet opening and outlet side with an outlet opening and at least three concentric and coaxial tubes in the housing, the housing having: (i) a first hole extending from the inlet opening to a first position within the housing, (ii) a second hole extending from the first position within the housing to a second position w…
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