Process for making dry and stable hemostatic compositions
US-2015367022-A1 · Dec 24, 2015 · US
Formation of stable submicron peptide or protein particles by thin film freezing
US8968786B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8968786-B2 |
| Application number | US-66538608-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 20, 2008 |
| Priority date | Jun 22, 2007 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
First claim
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What is claimed is: 1. A method for preparing a thin film comprising: dissolving a water soluble effective ingredient in one or more solvents, wherein the water soluble effective ingredient is a protein or peptide; spraying or dripping solvent droplets such that the effective ingredient is exposed to a vapor-liquid interface of less than 500 cm −1 area/volume; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the…
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- What does patent US8968786B2 cover?
- The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein …
- Who is the assignee on this patent?
- Johnston Keith P, Engstrom Joshua, Williams Iii Robert O, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K9/1658. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).