Ultrasensitive biological and chemical detection using surface plasmon resonance

US8965737B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8965737-B2
Application numberUS-201113284025-A
CountryUS
Kind codeB2
Filing dateOct 28, 2011
Priority dateOct 28, 2011
Publication dateFeb 24, 2015
Grant dateFeb 24, 2015

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Abstract

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A device, including sample and reference channels through which first and second solutions flow, respectively, the first solution including an analyte, the channels having a metal film in contact with the first and second solutions, the metal film configured with a linker to selectively bind the analyte; a light source whose output is modulated by an optical system, so that light is directed from the optical system alternately towards the sample and reference channels, surface plasmons within the metal film being created; a first photodetector that monitors the strength of the output from the light source; a second photodetector that collects optical signals reflected from the metal film; electronics that monitors output from the first and the second photodetectors, thereby detecting a noise-compensated difference in signals from the two channels; and a computer processor that determines, from analysis of the noise-compensated difference, presence of the analyte in the first solution.

First claim

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What is claimed is: 1. A device, comprising: sample and reference channels through which first and second solutions flow, respectively, wherein the first solution includes an analyte of interest, the channels having a metal film in contact with the first and second solutions, a surface of the metal film configured with a linker to selectively bind the analyte to the surface of the metal film; a light source whose output is modulated by an optical system, so that light is directe…

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What does patent US8965737B2 cover?
A device, including sample and reference channels through which first and second solutions flow, respectively, the first solution including an analyte, the channels having a metal film in contact with the first and second solutions, the metal film configured with a linker to selectively bind the analyte; a light source whose output is modulated by an optical system, so that light is directed fr…
Who is the assignee on this patent?
Feller Robert E, Knoesen Andre, Miller Robert D, and 1 more
What technology area does this patent fall under?
Primary CPC classification G01N21/05. Mapped technology areas include Physics.
When was this patent published?
Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).