Process for the synthesis of substituted gamma lactams

Patent metadata

Field	Value
Publication number	US-8962863-B2
Application number	US-201313970694-A
Country	US
Kind code	B2
Filing date	Aug 20, 2013
Priority date	Aug 21, 2012
Publication date	Feb 24, 2015
Grant date	Feb 24, 2015

Abstract

The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like.

First claim

What is claimed is:

1. A process for preparing a compound having the general structure (1)

wherein:
R 1 is H, C 1 -C 6 alkyl, or hydroxyethyl;
R 2 is C 1 -C 10 alkyl;
Ar is C 5 -C 10 arylene or heteroarylene; and
m and n are each independently 1-6;

comprising:
a) reacting compound (2)…

Assignees

• Allergan Inc

Inventors

• Dinh Danny T
• Garst Michael E
• Old David W
• Syage Elizabeth T
• Gorin Boris
• Lanthier Christopher M
• Oudenes Jan

Classifications

• C07D409/12 Primary

  Chemistry & Metallurgy · mapped topic

• H04N5/23229

  Electricity · mapped topic

• H04N5/23293

  Electricity · mapped topic

• Y02P20/55

  Cross-Sectional Technologies · mapped topic