Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use

Patent metadata

Field	Value
Publication number	US-8962859-B2
Application number	US-201213982096-A
Country	US
Kind code	B2
Filing date	Feb 13, 2012
Priority date	Feb 15, 2011
Publication date	Feb 24, 2015
Grant date	Feb 24, 2015

Abstract

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:

wherein variables A 1 , A 3 , A 5 , A 6 , A 8 , R 2 , R 7 , X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

First claim

What is claimed is:

1. A compound of Formula I

or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein
A 1 is CR 1 ;
A 3 is CR 3 ;
A 4 is CR 4 ;
A 5 is CR 5 ;
A 6 is CR 6 ;
A 8 is CR 8 ;
each of R 1 , R 4 , R 5 and R 8 , independently, is H, F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl or —C(O)C 1-6 -alkyl, wherein the C 1-6 -alkyl and C 1-6 -alkyl portion of —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl and —C(O)C 1-6 -alkyl are optionally substituted with 1-3 substituents of F, oxo or OH;
R 2 is Cl, Br, C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolyl, pyrrolidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl, cyclohexyl or —Si(CH 3 ) 3 , wherein the C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl and cyclohexyl are optionally substituted, independently, with 1-5 substituents of R 9 ;
each of R 3 and R 6 , independently, is H, halo, haloalkyl, haloalkoxyl, C 1-6 -alkyl, CN, OH, OC 1-6 -alkyl, S(O) o C 1-6 -alkyl, NHC 1-6 -alkyl or C(O)C 1-6 -alkyl;
R 7 is C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NHC(═O)R 9 , —C(═O)NHR 9 , —NHS(O) 2 R 9 , —S(O) 2 NHR 9 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolyl, pyrrolidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl or cyclohexyl, wherein the C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NHC(═O)R 9 , —C(═O)NHR 9 , —NHS(O) 2 R 9 , —S(O) 2 NHR 9 , —NH-phenyl, —NH-benzyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl and cyclohexyl are optionally substituted, independently, with 1-5 substituents of R 9 ;
each R 9 , independently, is halo, haloalkyl, CN, OH, NO 2 , NH 2 , acetyl, —C(O)NHCH 3 , oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl, tetrahydropyrrolyl, piperazinyl, oxetanyl or dioxolyl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkylamino-, C 1-6 dialkylamino-, C 1-6 alkoxyl, C 1-6 thioalkoxyl, phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetanyl or dioxolyl, is optionally substituted independently with 1-5 substituents of F, Cl, CN, NO 2 , NH 2 , OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, C 1-3 alkylamino-, C 1-3 dialkylamino, C 1-3 thioalkoxyl, or oxetanyl; and
—X—Y—Z— taken together is —C R 10 R 10 —C R 10 R 10 —C R 10 R 10 ; or
—Z— is absent and —X—Y— taken together is —C R 10 R 10 —C R 10 R 10 , —CR 10 ═CR 10 —, —NR 11 —CHR 10 - or —CHR 10 —NR 11 —, wherein
each R 10 , independently, is H, F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl or —C(O)C 1-6 -alkyl, wherein the C 1-6 -alkyl and C 1-6 -alkyl portion of —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl and —C(O)C 1-6 -alkyl are optionally substituted with 1-3 substituents of F, oxo or OH; and
each R 11 , independently, is H, C 1-6 -alkyl or CN.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
each of R 1 , R 4 , R 5 and R 8 , independently, is H, F, Cl, CF 3 , OCF 3 , methyl, ethyl, CN, OH, OCH 3 , SCH 3 , NHCH 3 or C(O)CH 3 ;
one of R 2 and R 7 , independently, is phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolyl, pyrrolidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl, cyclohexyl or —Si(CH 3 ) 3 , wherein the phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, 8-oxo-3-aza-bicyclo[3.2.1]oct-3-yl, aza-bicyclo[2.2.1]hept-5-yl, 2-oxo-7-aza-[3,5]-spironon-7-yl, cyclopentyl and cyclohexyl are optionally substituted, independently, with 1-3 substituents of R 9 ;
the other of R 2 and R 7 , independently, is C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NHC(═O)R 9 , —C(═O)NHR 9 , —NHS(O) 2 R 9 , —S(O) 2 NHR 9 , —NH-phenyl or —NH-benzyl, wherein the C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, CN, —OC 1-6 alkyl, —SC 1-6 alkyl, —NHC 1-6 alkyl, —N(C 1-3 alkyl) 2 , —NHC(═O)R 9 , —C(═O)NHR 9 , —NHS(O) 2 R 9 , —S(O) 2 NHR 9 , —NH-phenyl and —NH-benzyl are optionally substituted, independently, with 1-3 substituents of R 9 ;
each of R 3 and R 6 , independently, is H, halo, haloalkyl, haloalkoxyl, C 1-6 -alkyl, CN, OH, OC 1-6 -alkyl, SC 1-6 -alkyl, NHC 1-6 -alkyl or C(O)C 1-6 -alkyl; and
—X—Y—Z— taken together is —C R 10 R 10 —C R 10 R 10 —C R 10 R 10 ; or
—Z— is absent and —X—Y— taken together is —C R 10 R 10 —C R 10 R 10 , —CR 10 ═CR 10 , —NR 11 —CHR 10 - or —CHR 10 —NR 11 —, wherein
each R 10 , independently, is H, F, Cl, Br, CF 3 , OCF 3 , C 1-6 -alkyl, CN, OH, —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl or —C(O)C 1-6 -alkyl, wherein the C 1-6 -alkyl and C 1-6 -alkyl portion of —OC 1-6 -alkyl, —S(O) o C 1-6 -alkyl, —NHC 1-6 -alkyl and —C(O)C 1-6 -alkyl are optionally substituted with 1-3 substituents of F, oxo or OH; and
each R 11 , independently, is H, C 1-6 -alkyl or CN.

3. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R 2 is halo, haloalkyl, haloalkoxyl, C 1-6 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, or a ring selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, isoxazolyl, thiazolyl, pyranyl, dihydropyranyl, tetrahydropyranyl, furanyl, dihydrofuranyl, tetrahydrofuranyl, pyrrolyl, pyrrolidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, morpho

Assignees

• Epstein Oleg
• White Ryan
• Patel Vinod F
• Human Jason Brooks
• Amgen Inc

Inventors

• Epstein Oleg
• White Ryan
• Patel Vinod F
• Human Jason Brooks

Classifications

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61K31/353

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• C07D491/20 Primary

  Spiro-condensed systems · CPC title