Metabolically programmed metal chelators and uses thereof
US-10570104-B2 · Feb 25, 2020 · US
Luminescent substrate for luciferase
US8962854B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962854-B2 |
| Application number | US-201214240144-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 22, 2012 |
| Priority date | Aug 24, 2011 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.
First claim
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The invention claimed is: 1. A compound of the following formula or a salt thereof: wherein Z is R 1 is H or C 1-4 alkyl, R 4 is OH or NH 2 , and n is 0, 1, 2, or 3. 2. The compound or a salt thereof according to…
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- C07D277/12Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
- C12Q1/66Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8962854B2 cover?
- An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength tha…
- Who is the assignee on this patent?
- Nishiyama Shigeru, Saito Tsuyoshi, Maki Shojiro, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D277/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).