Gpx4 inhibitors, pharmaceutical compositions thereof, and their use for treating gpx4-mediated diseases
US-2024246901-A1 · Jul 25, 2024 · US
US8962850B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962850-B2 |
| Application number | US-201414175958-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 7, 2014 |
| Priority date | Apr 6, 2010 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R 1 and R 2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R 3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R 4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)
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The invention claimed is: 1. A method for producing a compound represented by formula (13) comprising reacting a compound represented by formula (9) with a halogenating agent in a presence of a compound represented by formula (12), wherein each of R 1 and R 2 independently represents a hydrogen atom, or an unsubstituted or substituted alkyl group, and R 1 and R 2 may form a…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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