Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics

Patent metadata

Field	Value
Publication number	US-8962837-B2
Application number	US-201113642025-A
Country	US
Kind code	B2
Filing date	Apr 15, 2011
Priority date	Apr 19, 2010
Publication date	Feb 24, 2015
Grant date	Feb 24, 2015

Abstract

The present invention relates to compounds having general formula I characterized in that

wherein in particular:
R 1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro.
R represents nitrogen
T-U represents C═C, V represents N, W represents C═O, R 2 represents Cl or H, R 3 =H and R 4 =Me,
A represents

wherein n=m=1, X represents —CH 2 — and E represents —CH—, and D represents oxygen,
along with the various isomers and mixtures thereof in any proportions, and the pharmaceutically acceptable salts thereof.

First claim

The invention claimed is:

1. A compound of general formula I

wherein
R1 is one or more substituents selected from the group consisting of trifluoromethyl, halogen, methyl, and nitro;
R is nitrogen; T-U is C═C; V is nitrogen; W is C═O; R2 is Cl or H; R3 is H; and R4 is Me;
A is…

Assignees

• Leroy Isabelle
• Dupont-Passelaigue Elisabeth
• Mialhe Samuel
• Junquero Didier
• Valeille Karine
• Pf Medicament

Inventors

• Leroy Isabelle
• Dupont-Passelaigue Elisabeth
• Mialhe Samuel
• Junquero Didier
• Valeille Karine

Classifications

• A61P3/10

  Human Necessities · mapped topic

• A61P9/00

  Human Necessities · mapped topic

• A61P3/06

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• A61P9/10

  Human Necessities · mapped topic