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Formation of N-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-N-protected amino ester
US8962836B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962836-B2 |
| Application number | US-201414212957-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2014 |
| Priority date | Mar 15, 2013 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for the synthesis of a bis N-protected 3,6-aminoalkyl-2,5-diketopiperazine of Formula I, wherein PG is selected from CBz, Boc, trifluoroacetyl, and acetyl and wherein n is from 1 to 8; the method comprising: adding a cyclic α-N protected active amino ester according Formula II…
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- C07D241/08Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D241/04Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8962836B2 cover?
- A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
- Who is the assignee on this patent?
- Mannkind Corp, Mannkind Corp
- What technology area does this patent fall under?
- Primary CPC classification C07D241/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).