Modulators of amyloid beta

Patent metadata

Field	Value
Publication number	US-8962834-B2
Application number	US-201313749865-A
Country	US
Kind code	B2
Filing date	Jan 25, 2013
Priority date	Feb 22, 2008
Publication date	Feb 24, 2015
Grant date	Feb 24, 2015

Abstract

The invention relates to compounds of formula

wherein the substituents are as described in claim 1 . Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

First claim

We claim:

1. A compound of formula I-A-1

wherein
R 2 is hydrogen, lower alkoxy, lower alkyl, cyano or halogen;
R 3 is lower alkyl, lower alkenyl, lower alkyl substituted by fluoro, or is 4H-benzo[1,4]oxazin-3-one, cycloalkyl optionally substituted by hydroxy, or is heterocycloalkyl, which heterocycloalkyl is optionally substituted by hydroxyl,
or is (CH 2…

Assignees

• Hoffmann La Roche

Inventors

• Baumann Karlheinz
• Flohr Alexander
• Goetschi Erwin
• Jacobsen Helmut
• Jolidon Synese
• Luebbers Thomas

Classifications

• A61P25/28

  Human Necessities · mapped topic

• A61P25/00

  Human Necessities · mapped topic

• C07D403/14

  Chemistry & Metallurgy · mapped topic

• C07D403/12 Primary

  Chemistry & Metallurgy · mapped topic

• C07D405/14

  Chemistry & Metallurgy · mapped topic