Deuterated compounds
US-2024270731-A1 · Aug 15, 2024 · US
US8962833B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962833-B2 |
| Application number | US-201013699368-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 25, 2010 |
| Priority date | May 25, 2010 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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The present invention provides novel salts of raltegravir, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides crystalline sodium salt of raltegravir, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a process for the preparation of amorphous sodium salt of raltegravir. The present invention further provides a process for the preparation of raltegravir potassium crystalline form H1.
Opening claim text (preview).
We claim: 1. A process for the preparation of raltegravir potassium crystalline form H1, comprising: a. suspending raltegravir in an non-aqueous alcoholic solvent to provide a suspension; b. adding potassium hydroxide to the suspension obtained in step (a) to provide a reaction mass; c. stirring the reaction mass obtained in step (b) at about 25 to 30° C. to provide a slurry, wherein stirring is for a time sufficient to produce raltegravir potassium crystalline form H1 and whe…
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