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Retinoid replacements and opsin agonists and methods for the use thereof
US8962691B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962691-B2 |
| Application number | US-201213619607-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 14, 2012 |
| Priority date | Mar 14, 2003 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
First claim
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What is claimed is: 1. A method of treating Leber Congenital Amaurosis (LCA) in an LRAT-defective human subject having a mutation in the gene encoding the LRAT protein, comprising: administering a therapeutically effective amount of a 9-cis-retinal to the LRAT-defective human subject, wherein the LRAT-defective human subject has a deficiency of endogenous 11-cis-retinal in the eye and the 9-cis-retinal forms a functional opsin/chromophore complex in the eye.…
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Frequently asked questions
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- What does patent US8962691B2 cover?
- Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
- Who is the assignee on this patent?
- Palczewski Krzysztof, Saperstein David A, Univ Washington
- What technology area does this patent fall under?
- Primary CPC classification A61K31/11. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).