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Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
US8962341B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962341-B2 |
| Application number | US-200913133244-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 10, 2009 |
| Priority date | Dec 12, 2008 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
Official abstract text for this publication.
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of screening for interstitial cystitis in a patient, said method comprising the steps of: (a) obtaining a fluid sample from a patient; (b) applying the sample to a detector device, wherein the detector device is a dipstick device, wherein the detector device comprises at least one detection reagent, wherein the detection reagent is a fragment of CKAP4 which comprises a polyhistidine tag at the end of said fragment of CKAP4, and wherein the det…
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- C07K9/005Primary
Chemistry & Metallurgy · mapped topic
- G01N33/5091Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8962341B2 cover?
- An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is…
- Who is the assignee on this patent?
- Zacharias David Alan, Planey Sonia Lobo, Commw Medical College, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K9/005. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).