Thioredoxin 1 epitope and monoclonal antibody specifically binding thereto
US-2024248090-A1 · Jul 25, 2024 · US
Real-time assay for the detection of botulinum toxin
US8962340B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962340-B2 |
| Application number | US-201313839827-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2013 |
| Priority date | Dec 3, 2012 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
Official abstract text for this publication.
A real-time portable and rapid detection assay to identify the presence of biologically active toxins such as botulinum toxins. The proteolytic activity of BoNT/A is measured using a peptide cleavage assay, where a fluorescent substrate is cleaved by BoNT/A, resulting in increased fluorescence. This fluorescence can be monitored in real-time using a fluorescence detection instrument, such as a real-time PCR system that has been modified to implement a detection algorithm specific to the identification of the target toxin.
First claim
Opening claim text (preview).
What is claimed is: 1. A device for detecting the presence of biologically active botulinum toxin, comprising: a chamber for receiving a test sample, said chamber including a peptide substrate comprising SEQ. ID NO. 1 that is labeled with a fluorophore and a quencher and has a cleavage site responsive to biologically active botulinum toxin positioned between said fluorophore and said quencher; a detector for measuring the amount of fluorescence emitted from said sample and outpu…
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Classifications
- C07K7/00Primary
Chemistry & Metallurgy · mapped topic
- G01N33/56911Primary
Physics · mapped topic
Physics · mapped topic
- C12Q1/37Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
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- What does patent US8962340B2 cover?
- A real-time portable and rapid detection assay to identify the presence of biologically active toxins such as botulinum toxins. The proteolytic activity of BoNT/A is measured using a peptide cleavage assay, where a fluorescent substrate is cleaved by BoNT/A, resulting in increased fluorescence. This fluorescence can be monitored in real-time using a fluorescence detection instrument, such as a …
- Who is the assignee on this patent?
- Src Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K7/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).