Methods and nucleic acid molecules for aav vector selection
US-2024417717-A1 · Dec 19, 2024 · US
US8962330B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962330-B2 |
| Application number | US-98102207-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 31, 2007 |
| Priority date | Dec 17, 2001 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
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The invention claimed is: 1. An adeno-associated virus (AAV) 8 viral vector comprising an AAV8 capsid having packaged therein a heterologous gene operably linked to regulatory sequences which direct its expression, wherein the heterologous gene encodes a low density lipoprotein receptor (LDLr), wherein the AAV8 capsid comprises a vp3 capsid protein having the sequence of aa 203 to 737 of SEQ ID NO:2, or a sequence which is at least 95% identical to said sequence of aa 203 to 737 o…
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