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Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
US8962285B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962285-B2 |
| Application number | US-201213525048-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 15, 2012 |
| Priority date | Aug 24, 2007 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for stereoselectively reducing substrate 3-ketothiolane-to product (R)-3-hydroxythiolane, which comprises contacting the 3-ketothiolane with the ketoreductase polypeptide comprising an amino acid sequence that is at least 90% identical to the reference sequence SEQ ID NO:4 and which has a serine at the residue position corresponding to X145, under suitable reaction conditions for reducing or converting the 3-ketothiolase to (R)-3-hydroxythiolane, wit…
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- C12P17/00Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Cross-Sectional Technologies · mapped topic
- C12Y101/01184Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8962285B2 cover?
- The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compo…
- Who is the assignee on this patent?
- Liang Jack, Jenne Stephane J, Mundorff Emily, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C12P17/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).