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Methods for detecting DNA orginating from different individuals

US8962280B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8962280-B2
Application numberUS-201313855974-A
CountryUS
Kind codeB2
Filing dateApr 3, 2013
Priority dateAug 31, 2001
Publication dateFeb 24, 2015
Grant dateFeb 24, 2015

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.

First claim

Opening claim text (preview).

What is claimed is: 1. A method for differentiating human DNA species originated from two different human individuals, the method comprising the steps of: (a) providing a sample that is obtained from one of the individuals and comprises cell-free human DNA species originated from the two individuals; (b) treating the sample with a bisulfite; (c) performing a methylation-specific polymerase chain reaction (PCR) to detect in the sample a methylated version and an unmethylated ve…

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What does patent US8962280B2 cover?
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic d…
Who is the assignee on this patent?
Univ Hong Kong Chinese
What technology area does this patent fall under?
Primary CPC classification C12Q1/6876. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).