Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
US-2015343056-A1 · Dec 3, 2015 · US
Solid-phase chelators and electronic biosensors
US8962279B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962279-B2 |
| Application number | US-65545909-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 30, 2009 |
| Priority date | Dec 30, 2009 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions.
First claim
Opening claim text (preview).
The invention claimed is: 1. A device comprising: a substrate comprising a plurality of individually-addressable electronic sensors wherein each electronic sensor has a surface and the sensor surface comprises attached molecules capable of selectively binding pyrophosphate ions, attachment sites for nucleic acid molecules to be sequenced wherein one attachment site is located in close proximity to one sensor, wherein in close proximity is between 0 nm to 100 nm of the sensor sur…
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- C12Q1/48Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8962279B2 cover?
- Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions atta…
- Who is the assignee on this patent?
- Liu David J, Su Xing, Wu Kai, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/48. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).