Compositions and methods for immunooncology
US-2024417722-A1 · Dec 19, 2024 · US
Methods of producing a secreted protein
US8962273B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962273-B2 |
| Application number | US-59939308-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 9, 2008 |
| Priority date | May 11, 2007 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
First claim
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What is claimed is: 1. A method of producing β-glucocerebrosidase or a β-glucocerebrosidase variant wherein the β-glucocerebrosidase variant is at least 90% identical to SEQ ID NO: 11 and has β-glucocerebrosidase activity, comprising culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses β-glucocerebrosidase or the β-glucocerebrosidase variant under conditions in which β-glucocerebrosidase or the β-glucocerebrosidase variant is produced, thereby…
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Chemistry & Metallurgy · mapped topic
- C12N15/1138Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8962273B2 cover?
- The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the varian…
- Who is the assignee on this patent?
- Reczek David J, Saftig Paul, Demaria Christine T, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N15/1138. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).