Atherosclerosis-targeted liposome nanocarrier delivery system and preparation method therefor
US-2024424132-A1 · Dec 26, 2024 · US
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US8962032B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8962032-B2 |
| Application number | US-201013515884-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 17, 2010 |
| Priority date | Dec 17, 2009 |
| Publication date | Feb 24, 2015 |
| Grant date | Feb 24, 2015 |
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Abstract
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There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.
First claim
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The invention claimed is: 1. A method of modulating an inflammatory response in a cell, the method comprising: providing sialic acid presented on a microparticle or nanoparticle to a cell such that a proinflammatory response is suppressed through reduction of TNF alpha levels or an anti-inflammatory response is increased through an increase in IL-10 levels in the cell, and wherein the sialic acid is NeuAcα2-8NeuAc. 2. The method as claimed in claim 1 wherein t…
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- What does patent US8962032B2 cover?
- There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment…
- Who is the assignee on this patent?
- Scott Christopher, Johnston James, Spence Shaun, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K47/61. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).